ชีวิตที่เรียบง่ายและแสนสงบของอดีตพลแม่นปืนนายหนึ่ง (เวสลี่ย์ สไนปส์) ได้สิ้นสุดลงแล้ว เมื่อเขาหลงกลตกปากรับคำจะสานต่อภารกิจสังหารหัวโจกผู้ก่อการร้ายให้สำเร็จ โดยที่เขาหารู้ไม่ว่า เขาจะโดนซ้อนแผนและถูกใส่ร้ายให้เป็นฆาตกรฆ่าตำรวจบิ๊กเนมรายหนึ่ง หายนะครั้งใหญ่ของชีวิตได้เริ่มต้นขึ้นแล้ว ลำพังแค่ 2 มือ 2 เท้า และการช่วยเหลือของเด็กสาววัยแค่ 12 ปี มันจะเพียงพอหรือสำหรับการทวงคืนความยุติธรรมให้กับตัวเอง
Retired C.I.A. black-ops hitman James Dial (Wesley Snipes) is living his life in seclusion on his ranch in Montana when he is offered the chance to redeem himself by his former employer, Jeremy Collins (Ralph Brown). A few years ago, Dial was a few seconds away from taking down notorious terrorist cell leader Ali Mahmud Jahar (Nikolai Sotirov) when when his carelessness allowed Jahar to escape, marking his mission as a failure. Now, Collins wants Dial to eliminate Jahar, who has been captured and is now in the custody of the Police in London, England. Provided with a safe house, passport, and an assistant named Terry Winchell (Richard Harrington), Dial is off to London to finish what he started several years ago. Disguised as a Priest, Dial gets in position in a church’s bell tower across the street from the building into which Jahar is being brought. When Jahar is brought out of his transport truck, his head is covered by a jacket, leaving Dial without a clean shot. Not wanting to fail again, Dial patiently waits for his opportunity. Moments later, Dial fatally shoots Jahar in the head. Because of a delay caused by a pair of cops, Winchell is late bringing the getaway car, and that brings attention to them fleeing the scene. After numerous attempts to stop the car, the Police open fire, killing Winchell. The car, now out of control, comes to crashing stop, injuring Dial. On the run and bleeding profusely, Dial makes his way to the safe house, where he meets curious twelve-year-old neighbor Emily Day (Eliza Bennett), who lives with her grandmother. Emily helps Dial stop the bleeding. Even though Jahar was eliminated, the mission was a failure to Collins because Dial was observed fleeing the scene on a security camera. In the U.S., Collins is being investigated for running a C.I.A. hit squad, and if word gets back about Dial and the death of Winchell, Collins will be exposed. Stopping at nothing to keep his name clean, Collins frames Dial for the murder of Detective Chief Superintendent Andrew Windsor (Charles Dance). Now a wanted man by Collins and the British Police, Dial must do whatever it takes to prove his innocence, knowing that Detective Inspector Annette Ballard (Lena Headey), Windsor’s vengeful daughter, is after him as well.